Global health review
A weekly round-up of all the latest global health research from MSF projects and beyond
29 March 2024
This week, to mark World Water Day, MSF contributes to a comment in The Lancet on this year’s theme of Water for Peace. The piece highlights how damage to water stations can disrupt health services, necessitating an interdisciplinary approach for restoration. In JAMA Diabetes & Endocrinology, MSF contributes to an investigation finding that certain insulin medications could be priced lower than they currently are which would contribute to wider access.
In Facial Plastic Surgery & Aesthetic Medicine, MSF discusses the outcomes of reconstructive facial surgery for patients with noma and assesses the impact on their quality of life. Meanwhile, research in BMC Health Services Research finds that health professionals commonly utilise routine health data for public health services in the Harari region, Ethiopia. In Toxins, a research article evaluates the tolerance of a snake antivenom under real-life conditions in Cameroon, with results appearing satisfactory. Finally, Open Forum Infectious Disease describes cholera deaths following mass vaccination in Uvira, Democratic Republic of the Congo.
Best regards,
Lydia Lampiri, Mohammad Salaymeh, Ononna Thuli and Holly Baker with MSF-authored article assistance from Patricia Kahn and Camryn Lewis.
All MSF-authored publications can be found on the MSF Science Portal, as well as recordings, abstracts and posters from the MSF Scientific Days International 2023 conference.
Antimicrobial resistance
RSTMH Transactions • Article: Antimicrobial resistance genetic determinants and susceptibility profile of Pseudomonas aeruginosa isolated from clinical samples in a tertiary hospital in Ogun State, Nigeria
Climate change and Planetary Health
WHO Bulletin • Perspective: A health financing policy agenda for climate mitigation and adaptation
PLOS Global Public Health • Article: Climate change, biodiversity loss, and Indigenous Peoples’ health and wellbeing: A systematic umbrella review
WHO Bulletin • Practice: Climate finance opportunities for health and health systems
JAMA Network Open • Article: Defining Roles and Responsibilities of the Health Workforce to Respond to the Climate Crisis
JAMA Network Open • Opinion: Health Professionals and the Climate Crisis
The BMJ • Feature: How climate change is changing vaccination planning
Conflict, migration and health
The BMJ • News: “Hospitals should never be battlegrounds,” says WHO amid raids on al-Shifa hospital
Conflict and Halth • Comment: The implications of the Sudan war on healthcare workers and facilities: a health system tragedy
Global health
WHO Bulletin • Perspective: A finance and health collaboration to counter pandemic threats
WHO Bulletin • Article: Analysing governments' progress on the right to health
WHO Bulletin • Perspective: Beyond GDP: understanding the interdependence of human and planetary health and the economy
PLOS Global Public Health • Article: COVID-19 self-testing: Countries accelerating policies ahead of WHO guidelines during pandemics, a global consultation
PLOS NTDs • Article: Epidemiological, clinical, and geographical characterization of Leprosy in the County of Santarém-Pará: Insights for effective control and targeted intervention
PLOS Global Public Health • Article: Mobilisation towards formal employment in the healthcare system: A qualitative study of community health workers in South Africa
BMJ Global Health • Article: Progress towards health equity in Vietnam: evidence from nationwide official health statistics, 2010-2020
Facial Plastic Sugery & Aesthetic Medicine • Article***MSF AUTHOR***: Prospective Outcomes of Noma Facial Reconstructive Surgery in Sokoto, Nigeria
PLOS Global Public Health • Opinion: Towards authentic institutional allyship by global health funders
The Lancet • Comment***MSF AUTHOR***: Water, health, and peace: a call for interdisciplinary research
HIV
PLOS Global Public Health • Article: A qualitative analysis of self-management needs of adolescents and young adults living with perinatally acquired HIV in rural, southwestern Uganda
Clinical Infectious Disease • Letter***MSF MENTIONS***: Is Same-Day Antiretroviral Therapy Initiation Beneficial? Methodological Aspects when Comparing Observational and Randomized Studies
PLOS Medicine • Article: Long-term HIV care outcomes under universal HIV treatment guidelines: A retrospective cohort study in 25 countries
PLOS Global Public Health • Article: Management practices in facilities providing HIV services to key populations in Kenya and Malawi: A descriptive analysis of management in community-based organizations
eClinicalMedicine • Article: Perinatal outcomes associated with pre-exposure prophylaxis for HIV prevention during pregnancy: a systematic review and meta-analysis
eBioMedicine • Article: Predictors of liver disease progression in people living with HIV-HBV co-infection on antiretroviral therapy
WHO Bulletin • Article: Provision of cervical cancer services for women living with HIV, Uganda
PLOS Medicine • Article: Safety and immunogenicity of a subtype C ALVAC-HIV (vCP2438) vaccine prime plus bivalent subtype C gp120 vaccine boost adjuvanted with MF59 or alum in healthy adults without HIV (HVTN 107): A phase 1/2a randomized trial
Infectious diseases
eClinicalMedicine • Article***MSF MENTIONS***: Carriage of third-generation cephalosporin-resistant and carbapenem-resistant Enterobacterales among children in sub-Saharan Africa: a systematic review and meta-analysis
Open Forum Infectious Diseases • Article***MSF MENTIONS***: Cholera Deaths During Outbreaks in Uvira, Eastern Democratic Republic of the Congo, 10–35 Months After Mass Vaccination
RSTMH Transactions • Article: Comparison of miRNA profiles in the immune response of pediatric acute appendicitis and pediatric enterobiasis patients caused by Enterobius vermicularis
PLOS Global Public Health • Article: Predictors to Intensive Care Unit admission among patient with coronavirus disease in Sukraraj Tropical and Infectious Disease Hospital, Nepal: A case-control study
Malaria
Malaria Journal • Article: Cerebral malaria presenting as nonconvulsive status epilepticus: a case report
Malaria Journal • Article: Community and health worker perspectives on malaria in Meghalaya, India: covering the last mile of elimination by 2030
Malaria Journal • Article: Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo
BMJ Global Health • Article: Reduction of malaria case incidence following the introduction of clothianidin-based indoor residual spraying in previously unsprayed districts: an observational analysis using health facility register data from Côte d’Ivoire, 2018–2022
Malaria Journal • Article: The effect of COVID-19 on malaria cases in Zambia: a mixed effect multilevel analysis
Maternal and child health
eBioMedicine • Article: Co-occurrence of and factors associated with health risk behaviors among adolescents: a multi-center study in sub-Saharan Africa, China, and India
The Lancet Regional Health-Southeast Asia • Article: Effect of a parenting and nutrition education programme on development and growth of children using a social safety-net platform in urban Bangladesh: a cluster randomized controlled trial
The Lancet Global Health • Article: Effectiveness of bubble continuous positive airway pressure for treatment of children aged 1–59 months with severe pneumonia and hypoxaemia in Ethiopia: a pragmatic cluster-randomised controlled trial
PLOS Global Public Health • Article: Experiences of teachers and students on school closures and its consequences during the COVID-19 pandemic in Nyarugusu refugee camp, Tanzania
The Lancet • Article: Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study
PLOS Global Public Health • Article: Predictors of neonatal mortality in Ethiopia: Cross sectional study using 2005, 2010 and 2016 Ethiopian demographic health survey datasets
SSM - Qualitative Research in Health • Article***MSF & EPICENTRE MENTIONS***: Reasons for delay in reaching healthcare with severe abortion-related morbidities: Qualitative results from women in the fragile context of Jigawa state, Nigeria (AMoCo)
PLOS Global Public Health • Article: The WHO atlas for female-genital schistosomiasis: Co-design of a practicable diagnostic guide, digital support and training
PLOS Global Public Health • Article: Validation of the Emergency Department-Paediatric Early Warning Score (ED-PEWS) for use in low- and middle-income countries: A multicentre observational study
Mental health
JAMA Pediatrics • Article: Mental Health of Adolescents Exposed to the War in Ukraine
WHO Bulletin • Practice: Towards a well-being economy for mental health
Neglected tropical diseases
WHO Bulletin • Article: Age-group associations of schistosomiasis prevalence from trial data, Côte d’Ivoire, Kenya and the United Republic of Tanzania
The Lancet Infectious Diseases • Article: Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study
PLOS NTDs • Article: Harnessing Schistosoma-associated metabolite changes in the human host to identify biomarkers of infection and morbidity: Where are we and what should we do next?
PLOS NTDs • Article: Impact of annual community-directed treatment with ivermectin on the incidence of epilepsy in Mvolo, a two-year prospective study
RSTMH Transactions • Article: Motivation–opportunity–ability–behaviour of community members and program implementers towards mass drug administration for lymphatic filariasis elimination in India: a systematic review and implementation priority
PLOS NTDs • Article: Sero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda
Toxins • Article***EPICENTRE MENTIONS***: Snakebites in Cameroon: Tolerance of a Snake Antivenom (Inoserp™ PAN-AFRICA) in Africa in Real-Life Conditions
RSTMH Transactions • Article: Spatial-temporal distribution of visceral leishmaniasis in Rio de Janeiro, Brazil, 2001–2020: expansion and challenges
WHO Bulletin • Practice: Target product profiles: leprosy diagnostics
PLOS NTDs • Article: The role of point-of-care ultrasound in the assessment of schistosomiasis-induced liver fibrosis: A systematic scoping review
Non-communicable diseases
JAMA Diabetes and Endocrinology • Article***MENTIONS MSF***: Estimated Sustainable Cost-Based Prices for Diabetes Medicines
The Lancet Regional Health-Southeast Asia • Article: Preliminary results of hypofractionated radiotherapy in breast cancer in Chandigarh, India: single-centre, non-inferiority, open-label, randomised, phase 3 trial
PLOS Global Public Health • Article: Social network enhanced behavioral interventions for diabetes and obesity: A 3 arm randomized trial with 2 years follow-up in Jordan
Tropical Medicine and International Health • Article: Transfers between health facilities of people living with diabetes attending primary health care services in the Western Cape Province of South Africa: A retrospective cohort study
Outbreaks
PLOS Glboal Public Health • Article: A time of decline: An eco-anthropological and ethnohistorical investigation of mpox in the Central African Republic
BMJ Global Health • Article: Building citizen science intelligence for outbreak preparedness and response: a mixed-method study in nine countries to assess knowledge, readiness and feasibility
WHO Bulletin • Review: Financing for pandemic preparedness and response measures: a systematic scoping review
Research and reporting
PLOS Global Public Health • Article: Adaptation of the Client Diagnostic Questionnaire for East Africa
BMJ Global Health • Article: Aligning the principles and practice of research integrity and research fairness in global health: a mixed-methods study
PLOS Global Public Health • Article: Anaesthesia delivery systems in low and lower-middle-income Asian countries: A scoping review of capacity and effectiveness
PLOS Global Public Health • Article: Assessing the influence of COVID-19 lockdown measures on cognition and behavior in school age children in Arba Minch Health and Demographic Surveillance site, Southern Ethiopia: A cross-sectional study
eClinicalMedicine • Article: Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspective
PLOS Global Public Health • Article: Exploring different health care providers´ perceptions on the management of diarrhoea in cholera hotspots in the Democratic Republic of Congo: A qualitative content analysis
The Lancet • Article: Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
WHO Bulletin • Article: Improving the management of open tibia fractures, Malawi
PLOS Global Public Health • Article: Leveraging qualitative approaches to guide sustainable international research collaborations
BMC Health Services Research • Article***MSF MENTIONS***: Utilization of routine health data and its determinants among healthcare workers in public health facilities of harari region, eastern Ethiopia
Tuberculosis
eClinicalMedicine • Article: Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study
eClinicalMedicine • Article***EPICENTRE MENTIONS***: Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study
eClinicalMedicine • Article: Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study
The Lancet Infectious Diseases • Article: Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021
PLOS Medicine • Article: Quantifying gaps in the tuberculosis care cascade in Brazil: A mathematical model study using national program data
Clinical Infectious Disease • Article***MSF MENTIONS***: The Safety and Tolerability of Linezolid in Novel Short-Course Regimens Containing Bedaquiline, Pretomanid, and Linezolid to Treat Rifampicin-Resistant Tuberculosis: An Individual Patient Data Meta-analysis
Vaccines
Vaccine X • Comment***EPICENTRE MENTIONS***: A conceptual framework to model social determinants of COVID-19 vaccination uptake among underserved homeless populations
PLOS Global Public Health • Article: Cross-sectional study on intention to be vaccinated against Coronavirus Disease 2019 (COVID-19) in Benin and Senegal: A structural equation modeling (SEM)
WHO Bulletin • Article: Global vaccine coverage and childhood survival estimates; 1990–2019
The Lancet Infectious Diseases • Article: Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial
Zika
PLOS NTDs • Article: Assessing vulnerability for future Zika virus outbreaks using seroprevalence data and environmental suitability maps