What is the MSF Online Journal Club?

The MSF journal club is a forum for debate and discussion of articles relevant to MSF's medical humanitarian programmes.

It aims to bring together MSF programme staff with experts around the world to keep informed of the latest research and opinion around delivering care in resource-limited, emergency Our next MSF Twitter Journal Club is next Friday 15 April at 12.30pm BST.  


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When and where?

The journal club meets monthly and takes place on Twitter via @MSFsci using the hashtag #MSFjc. Our next MSF Twitter Journal Club is next Friday 15 April at 12.30pm BST.  

We will be discussing two papers:

Multidrug-Resistant Tuberculosis Treatment Outcomes in Relation to Treatment and Initial Versus Acquired Second-Line Drug Resistance

Xpert MTB/RIF Results in Patients With Previous Tuberculosis: Can We Distinguish True From False Positive Results?

Firstly, how reliable is Xpert in detecting relapse – previous studies showed high culture negative rates and this larger study confirms the finding of high rates of culture negativity. So when to restart therapy in failed DR patients – and is it safe to stop treatment in patients who have been restarted on therapy? Or should we always wait for culture? Are there alternatives for diagnosing relapse?

Second, not all DR TB is equal, the second CID paper shows that outcomes in those previously treated are much worse than in those with (presumable) transmitted resistance. So how do you balance DST with treatment history? Are there other confounders here (e.g. the DST of the drugs we can’t reliably test). and conflict settings.


New to Twitter?

Download our 'how-to guide', which will tell you everything that you need to know about getting started on Twitter. 

Twitter is a social media service where users can post 'tweets' that are 140 characters in length. Users can group tweets by any given topic using a "hashtag", which is a hash sign (#) followed by a given word or phrase. 

For the MSF Online Journal Club all tweets should be marked with #MSFjc and this will create a virtual discussion board, enabling all participants to track our conversation. 


Previous journal club discussions

Directly observed therapy for treating tuberculosis / Storify

Classification of antituberculosis drugs: a new proposal based on the most recent evidence / Storify

Optimal Duration of Anti-TB Treatment in Patients With Diabetes: Nine or Six Months?  / Storify

Efficacy, safety and tolerability of linezolid for the treatment of XDR-TB: a study in China / Storify

Loss from Treatment for Drug Resistant Tuberculosis: Risk Factors and Patient Outcomes in a Community-Based Program in Khayelitsha, South Africa / Storify

Effect of the Ebola-virus-disease epidemic on malaria case management in Guinea, 2014: a cross-sectional survey of health facilities / Storify

Clofazimine for the treatment of multidrug-resistant tuberculosis: prospective, multicenter, randomized controlled study in China / Review / Storify

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine / Review / Storify

Improving Outcomes for Multidrug-Resistant Tuberculosis: Aggressive Regimens Prevent Treatment Failure and Death  / Review / Storify


If you require further assistance or have any questions about the journal club please contact Kim West at kim.west@london.msf.org


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