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Snapshot 17/08/2016

This week in The Lancet, an MSF-authored letter discusses the possibility that Ebola virus can persist in some survivors through defective-interfering genomes, and in Emerging Infectious Disease, MSF examines the Ebola outbreak that occurred in the Democratic Republic of the Congo in 2014. An article in Epidemiology and Infection reports on multidrug-resistance surgical site infections in an MSF surgery project in Nigeria.

In PLOS ONE, MSF assesses the feasibility of implementing a strategy for detecting antiretroviral therapy failure using viral load testing in HIV-infected patients before changing to tenofovir for first-line treatment, and a paper describes the profile of participants and publication outputs from the Structured Operational Research and Training Initiative (SORT IT).

Friday is World Humanitarian Day and The Lancet marks this by reflecting on the global response to the refugee and migrant crisis. The health and humanitarian situation in Borno State, northeast Nigeria, is also discussed and is likely to worsen in the coming months unless aid can reach those in the region.

Do not forget that the MSF/LSHTM collaborative symposium on improving care of people with non-communicable diseases in humanitarian settings is on September 2nd – you can watch live online wherever you are in the world. Register to watch here.



The Lancet • Corr***MSF Author***: Defective interfering genomes and Ebola virus persistence

Emerging Infectious Disease • Article***MSF Authors***: Ebola Virus Disease, Democratic Republic of the Congo, 2014

NEJM • Report: After Ebola in West Africa — Unpredictable Risks, Preventable Epidemics

PLOS Medicine • Research: Associations between Mental Health and Ebola-Related Health Behaviors: A Regionally Representative Cross-sectional Survey in Post-conflict Sierra Leone



JAMA • Article: More Insights Into Zika Virus Infection and Birth Outcomes

BMJ • News: Brazil to investigate if other factors act with Zika to cause congenital defects

BMJ • Article: Congenital Zika syndrome with arthrogryposis: retrospective case series study

BMC Medicine • Article: The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact



PLOS ONE • Research ***MSF Author***: Is There a Need for Viral Load Testing to Assess Treatment Failure in HIV-Infected Patients Who Are about to Change to Tenofovir-Based First-Line Antiretroviral Therapy? Programmatic Findings from Myanmar

PLOS Medicine • Policy Forum: Building from the HIV Response toward Universal Health Coverage

PLOS Medicine • Policy Forum: Transitioning to Country Ownership of HIV Programs in Rwanda

PLOS Medicine • Research: Accelerating the Uptake and Timing of Antiretroviral Therapy Initiation in Sub-Saharan Africa: An Operations Research Agenda

TM&IH • Research: Psychological interventions for post-traumatic stress disorder in people living with HIV in Resource poor settings: a systematic review



Epidemiology & Infection • Article***MSF Authors***: Multidrug-resistant surgical site infections in a humanitarian surgery project



Lancet Infectious Disease • Article: The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis

IJTLH • Research: Measuring ventilation and modelling M. tuberculosis transmission in indoor congregate settings, rural KwaZulu-Natal

IJTLH • Research: Occupational exposure and tuberculosis among medical residents in a high-burden setting: an open-cohort study

IJTLH • Research: An integrated community TB-HIV adherence model provides an alternative to DOT for tuberculosis patients in Cape Town

IJTLH • Research: Trends in tuberculosis case notification and treatment outcomes after interventions in 10 zones of Ethiopia

IJTLH • Research: Community knowledge, attitudes and practices in relation to tuberculosis in Cameroon

IJTLH • Research: Higher cost of implementing Xpert®MTB/RIF in Ugandan peripheral settings: implications for cost-effectiveness


Neglected Tropical Diseases

PLOS NTD • Research: Factors Associated with Ivermectin Non-Compliance and Its Potential Role in Sustaining Onchocerca volvulus Transmission in the West Region of Cameroon

American Society for Microbiology • Research: Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy



Malaria Journal • Research: Feasibility and implementation of community-based malaria case management with integrated vector control in the Democratic Republic of Congo

Malaria Journal • Research: Evaluation of the operational challenges in implementing reactive screen-and-treat and implications of reactive case detection strategies for malaria elimination in a region of low transmission in southern Zambia

Malaria Journal • Research: Sustaining control: lessons from the Lubombo spatial development initiative in southern Africa

Malaria Journal • Research: Eave tubes for malaria control in Africa: an introduction

Malaria Journal • Research: A comparison of malaria prevalence, control and management strategies in irrigated and non-irrigated areas in eastern Kenya

Malaria Journal • Research: A framework for evaluating the costs of malaria elimination interventions: an application to reactive case detection in Southern Province of Zambia, 2014


Health in a humanitarian setting

The Lancet • Editorial: Refugee and migrant crisis: the deficient global response

The Lancet • World Report: Health crisis intensifying in Nigeria's Borno State

The Lancet • World Report: Refugees need health cards, say German doctors



PLOS ONE • Research ***MSF Author***: Building Global Capacity for Conducting Operational Research Using the SORT IT Model: Where and Who?


Compiled by:  Holly Baker, Jeffrey Hau,  & Kim West

Médecins Sans Frontières (MSF) UK

MSF-authored article list assistance:
Frances Williams, Patricia Kahn
Médecins Sans Frontières (MSF) USA

If you are unable to access any of these articles please contact Kaai Meier-de Kock ( at the MSF-DE Library and Research Centre or Aline Raymond ( at OCB's IDC (Information and Documentation Centre) who will aim to send you the article within 48 hours.




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