MSF calls on endemic countries to diagnose and treat Chagas patients and demands more research and development of new medicines, rapid diagnosis tests and cure tests.
Every year, Chagas kills 14,000 people and it is estimated that 10-15 million people are infected. Today, Médecins Sans Frontières (MSF) launches its campaign Chagas: it’s time to break the silence. The disease is endemic in several Latin American countries but worldwide migration means that more and more cases are being reported in the USA, Europe, Australia and Japan. Chagas is a potential killer, but so far governments have focused on prevention and vector control rather than treatment of patients.
MSF team visits households in search of potential Chagas affected children. Bolivia, 2006.
Juan Carlos Tomasi
MSF calls on endemic countries to end the neglect of Chagas sufferers and support diagnosis and treatment for affected people, rather than focusing solely on vector control. Integrating Chagas care into primary healthcare facilities would improve patient access to treatment. MSF also calls for further Research and Development (R&D) efforts into new drugs, rapid diagnosis tests to use in remote settings and better cure tests for one of the world’s most neglected diseases.
About the disease:
Chagas disease is caused by the Trypanosoma cruzi parasite. In most Latin American countries, the disease is transmitted by the ‘kissing bug’ vector, although transmission is also possible from mother to child, through blood transfusions, organ transplants and contaminated food.
Chagas patients may be asymptomatic for years but during the chronic phase of the disease one third develop serious health problems (mainly heart and intestinal complications) that can lead to death. “One of the main problems we have is that for years patients have no symptoms so they do not know they are sick and receive no treatment. Active case detection is essential to find and treat infected people,” explains Dr. Nines Lima, MSF Chagas officer.
About the treatment:
The sooner the disease is detected, the more effective the treatment. The only two existing drugs – benznidazol and nifurtimox – were developed over 35 years ago through research not specifically focusing on Chagas. Although these medicines are very effective in newborn and breastfeeding children, only about 60 to 70 per cent of adolescents and adults are successfully treated. The older the patients are, the greater the likelihood they will experience side effects from the drugs. “Doctors do not treat children, let alone adults, for fear of side effects," said Dr. Tom Ellman, MSF Head of Mission in Bolivia. "We are showing that these effects are manageable in both cases. Leaving patients untreated is no longer ethical.”
Lack of research:
The disease is mainly poverty related, and therefore Chagas has been absent from political agendas. Research and Development must be boosted in order to develop new rapid diagnosis tests, better medicines and new cure tests to address this disease more effectively. “New ways to boost R&D and better tools to care for patients need to be found,” said Gemma Ortiz, head of the MSF Chagas campaign.